| The usefulness of the colour change plaster (NeuroCheck￠c) for the diagnosis of cardiac autonomic neuropathy in type 2 diabetes |
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Hyun Jung Kim, Yeun Hyuk Lim, Hyo Jung Oh, Byung Soo Kim, Ha Young Kim, Byoung Hyun Park, Chung Gu Cho |
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Seoul National University College of Medicine |
| 제2형 당뇨병 환자에서 심혈관계 자율신경병증의 진단에 있어 Colour Change Plaster (NeuroCheck?) 검사의 유용성에 관한 연구 |
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김현정, Yeun Hyuk Lim, Hyo Jung Oh, Byung Soo Kim, Ha Young Kim, Byoung Hyun Park, Chung Gu Cho |
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| Abstract |
Background : Recently, the colour change plaster (NeuroCheck￠c) has been introduced, which measures sweat production on the basis of a colour change from blue to pink. This new test was useful to detect of diabetic peripheral neuropathy. The aim of this study was to evaluate the
usefulness of the colour change plaster (NeuroCheck￠c) for the diagnosis of cardiac autonomic neuropathy in type 2 diabetic patients.
Methods
: This study include 35 type 2 diabetic patients (10 male, 25 female) with a mean age of 55¡¾14.9 years and a mean diabetes duration of 11.8¡¾8.8 years. Cardiac autonomic neuropathy was diagnosed by means of Ewing's method. Peripheral autonomic neuropathy (Sudomotor function
abnormality) was assessed by means of time (more than 600 seconds) until complete colour change in the indicator test.
Results
: Peripheral autonomic neuropathy was diagnosed in 23 patients (65.7%). Time until starting colour change of plaster in normal and abnormal sudomotor patients were 38.3¡¾33.7 sec and 367.1¡¾470.3 sec (p<0.05). Time until completing colour change of plaster in normal and abnormal sudomotor patients were 372.5¡¾198.8 sec and 1677.4¡¾711.9 sec (p<0.05). The autonomic score of two groups were 2.4¡¾2.3, 4.6¡¾2.2 (p<0.05). Sudomotor abnormal group was older than normal (59.2¡¾11.7 yrs, vs 47¡¾17.4 yrs). Presence of retinopathy was related with sudomotor abnormality. Peripheral autonomic neuropathy was related with parasympathetic cardiac autonomic neuropathy. Sudomotor function abnormality was related with definite cardiac autonomic neuropathy, but it was not related with early cardiac autonomic neuropathy. The sensitivity, specificity, positive predictive value and negative predictive value of colour change plaster in the diagnosis of definitive cardiovascular autonomic neuropathy was 86.7%, 62.5%, 68.4% and 83.3%, respectively.
Conclusions
: The colour change plaster (NeuroCheck￠c) is not useful for the early diagnosis of cardiac autonomic neuropathy in type 2 diabetic neuropathy, but it may be possible for the screening test of definite cardiac autonomic neuropathy.
Key Words : Cardiac autonomic neuropathy, Colour change plaster, Type 2 diabetes |
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