| Clinical spectrum and risk factors of erosive and non-erosive GERD in health check-up subjects |
|
Hyun Young Kim, Nayoung Kim, Sun Mi Kim, Ji Hyun Seo, Young Soo Park, Jin Hyok Hwang, Jin Wook Kim, Sook Hyang Jung, Dong Ho Lee |
|
고려대학교 의과대학 내과학교실 |
| 원저:건강 검진자에서의 미란성 및 비미란성 위식도역류질환의 임상적 특성 및 위험인자 |
|
김현영, Nayoung Kim, Sun Mi Kim, Ji Hyun Seo, Young Soo Park, Jin Hyok Hwang, Jin Wook Kim, Sook Hyang Jung, Dong Ho Lee |
|
|
|
|
|
|
| Abstract |
Background : This study was prospectively performed to evaluate the clinical spectrum and risk
factors of gastroesophageal reflux disease (GERD) in health check-up subjects.
Methods
: A prospective survey was performed for 752 subjects, aged 18-79 years, who visited
the health promotion center. The subjects were asked to complete a questionnaire, and the risk of
GERD was calculated by logistic regression analysis with regard to several variables, including
smoking, alcohol, exercise, body mass index, fasting glucose, cholesterol, triglyceride and anti-H.
pylori immunoglobulin G (IgG). Non-erosive reflux disease (NERD) was defined as the presence of
heartburn and/or acid regurgitation for at least once per week.
Results
: 752 subjects were classified into three groups: 65 erosive reflux disease (ERD) subjects
(8.6%), 66 NERD subjects (8.8%) and 621 control group subjects (82.6%). For the 65 ERD subjects,
typical reflux symptoms were found in 19 (29.2%), less frequent reflux or atypical symptoms were
found in 38 (58.5%) and no symptoms were found in 8 (12.3%). A Los Angeles grade A score was
noted in 48 subjects (73.8%), a B score was noted in 11 (17.0%), and a C score was noted in 6
(9.2%). There was no correlation between the grade of reflux esophagitis and the severity of
symptoms. The positive rate of H. pylori IgG in the ERD was 36.4%, and this was significantly
lower than the rates for the NERD (60%) and control groups (65.3%); this resulted in the odds ratio
of ERD in the absence of H. pylori infection to be 5.079 (95% CI: 1.907-13.530).
Conclusions
: The prevalence rate of GERD in health check-up subjects was 17.4%. There was
no correlation between the grade of ERD and the severity of the reflux symptoms. The relative risk
of GERD in Koreans was significantly low in the H. pylori IgG positive subjects.(Korean J Med
71:491-500, 2006)
Key Words : Gastroesophageal reflux, Erosive reflux disease, Non-erosive reflux disease |
|
PDF Links
Full text via DOI
Download Citation
