| Association between apolipoprotein E genetic polymorphism and the development of microalbuminuria in type 2 diabetic patients |
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Mikwang Kwon, Sang Youl Rhee, Suk Chon, Seungjoon Oh, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim |
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고려대학교 의과대학 내과학교실 |
| 원저 : 제2형 당뇨병 환자에서 아포지단백 E의 유전자 다형성과 미세알부민뇨 발생과의 연관성 |
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권미광, Sang Youl Rhee, Suk Chon, Seungjoon Oh, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim |
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| Abstract |
Background : Apo E genetic polymorphism has been proposed as the one of the risk factors for diabetic nephropathy. We studied the association between Apo E genetic polymorphism and the development of microalbuminuria, which is the early stage of diabetic nephropathy.
Methods
: Fifty eight subjects with normoalbuminuria and Thirty six subjects with microalbuminuria were enrolled. They were all type 2 diabetic patients who had normal renal function and a history of diabetes longer than a 10 years duration. We examined the mean HbA1c, total cholesterol and triglyceride levels for 10 years, and we also examined several clinical characteristics. We determined the Apo E genotype by performing real time PCR.
Results
: In the microalbuminuria group, compared with the normoalbuminuria group, the HbA1c (7.6¡¾1.3% vs 7.0¡¾ 0.9%, respectively, p=0.012) and mean creatinine (1.2¡¾0.7 mg/dL vs 1.0¡¾0.2 mg/dL, respectively, p=0.004) levels were significantly higher, and the frequencies of the e3/e4 genotype (5.6% vs 20.7%, respectively, p=0.045) and the E4 carriers (5.9% vs 22.8%, respectively, p=0.035) were significantly lower. On logistic regression analysis, the crude odds ratio of being an E2 carrier and being an E4 carrier were 0.833 (95% CI: 0.245-2.833) and 0.205 (95% CI: 0.043-0.986), respectively.
However, the odds ratio after adjusted by HbA1c, hypertension, total cholesterol and triglyceride were 0.664 (95% CI: 0.134-3.289) and 0.365 (95% CI: 0.061-2.187), respectively. There were no correlations between being an Apo E carrier and the lipid levels in the healthy controls and diabetic patients.
Conclusions
: Being an E4 carrier might play a role in protecting against the development of microalbuminuria in type 2 diabetic patients and there was no correlation among the Apo E genetic polymorphisms and the lipid levels.(Korean J Med 72:511-521, 2007)
Key Words : Diabetes mellitus, Type 2, Apo E genetic polymorphisms, Microalbuminuira |
| Key Words:
Diabetes mellitus, Type 2, Apo E genetic polymorphisms, Microalbuminuira |
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