| The role of cardiovascular risk factors in systemic lupus erythematosus |
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Shin-Seok Lee |
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한림대학교 의과대학 내과학교실 강동성심병원 심혈관센터 |
| 종설 : 전신성 홍반성 루푸스에서 심혈관 위험인자들의 역할 |
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이신석 |
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| Abstract |
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The survival of patients with systemic lupus erythematosus (SLE) has improved dramatically over the last few decades. However, the mortality rates of SLE patients remain three times that of an age- and gender-matched population. As the lifespan of SLE patients continues to increase, death due to cardiovascular disease (CVD) has attained increasing importance. In several SLE cohorts, the prevalence of clinical coronary artery disease (CAD) has been shown to range from 6% to 10%. Compared with women in the general population, women with SLE are estimated to be 5-8-times more likely to develop CAD, with this risk being particularly marked in women younger than 55 years of age. These increased risks of CVD for SLE patients cannot be fully explained by traditional cardiovascular risk factors alone and other factors, such as inflammatory factors, are presumed to contribute to these risks. Among the inflammatory factors, high-sensitivity C-reactive protein (hsCRP) has proven to be the most powerful marker for future cardiovascular events in patients with SLE. It is suggested that the addition of hsCRP to standard cardiovascular risk factors will facilitate the identification of lupus patients at risk for future cardiovascular events. (Korean J Med 73:556-564, 2007) |
| Key Words:
Systemic lupus erythematosus, cardiovascular risk factor, C-reactive protein |
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