Korean J Med > Volume 76(3); 2009 > Article
The Korean Journal of Medicine 2009;76(3):365-369.
Allopurinol-induced agranulocytosis in a patient on peritoneal dialysis
Jin Kyung Kim, Young Ki Lee, Jung Woo Noh, Byung Moo Ahn, Jung Han Kim, Young Ok Jung, Min-Jeong Park
복막투석 환자에서 allopurinol 복용 후 발생한 무과립구증 1예
김진경, 이영기, 노정우, 안병무, 김정한, 정영옥, 박민정
Abstract
Agranulocytosis is a rare, but sometimes dangerous, adverse reaction to allopurinol. We report the unusual case of a 43-year-old man with agranulocytosis, who received allopurinol while undergoing peritoneal dialysis. The bone marrow biopsy indicated that the agranulocytosis was drug-induced. After ceasing all drugs, isolating the patient, and administering granulocyte colony-stimulating factor (G-CSF), the leukocyte count returned to normal. A relationship between allopurinol therapy and agranulocytosis was presumed.
Key Words: Allopurinol; G-CSF (granulocyte colony-stimulating factor); Agranulocytosis


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