| Update on NSAIDs Related Peptic Ulcers |
|
Dong Wook Choi1, Sung Chul Park1, Hoon Jai Chun2 |
1Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea
2Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea |
| 비스테로이드소염제 관련 소화성 궤양의 최신지견 |
|
최동욱1, 박성철1, 전훈재2 |
1강원대학교 의학전문대학원 내과학교실
2고려대학교 의과대학 내과학교실 |
Correspondence:
Hoon Jai Chun, Tel: +82-2-920-6555, Fax: +82-2-953-1943, Email: drchunhj@chol.com
|
|
|
|
|
| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
|
| Abstract |
|
Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic, antipyretic, and anti-inflammatory properties and are widely used for treating musculoskeletal and cardiovascular diseases. Notwithstanding these therapeutic efficacies, gastrointestinal toxicity is the major health problem associated with NSAID use. NSAID-related peptic ulcers are a well-known complication due to direct mucosal injury and cyclooxygenase inhibition. Risk factors for NSAID-related peptic ulcers include a prior history of peptic ulcer; age > 65 years; high-dose NSAID therapy; and concurrent use of aspirin (including low dose), corticosteroids, or anticoagulants. In addition, Helicobacter pylori infection is an independent risk factor; therefore, eradication therapy is recommended in high-risk patients using NSAIDs. Currently, misoprostol, H2-receptor antagonists, proton pump inhibitors, and COX-2 selective inhibitors are used to prevent and treat NSAID-related peptic ulcers. Further, strategic approaches are required through appropriate NSAID use and risk factor stratification to prevent NSAID-related peptic ulcers and associated complications. (Korean J Med 2014;86:664-672) |
| Key Words:
Non-steroidal anti-inflammatory drugs; Peptic ulcer; Treatment; Prevention |
| 주제어:
비스테로이드소염제; 소화성 궤양, 치료; 예방 |
|
PDF Links
Full text via DOI
Download Citation
