| IgG4-Related Tubulointerstitial Nephritis Accompanied by
Henoch-Schönlein Purpura |
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Hyun Yang, Soo Kyoung Choi, Bokyoung Kim, Ji Yeon Yoo, Eun Sil Koh, Yoon Sik Chang, Sungjin Chung |
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Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea |
| 헤노흐-쇤라인 자색반과 동반된 IgG4 연관 요세관간질 신염 |
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양 현, 최수경, 김보경, 유지연, 고은실, 장윤식, 정성진 |
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가톨릭대학교 의과대학 내과학교실 |
Correspondence:
Sungjin Chung, Tel: +82-2-3779-2413, Fax: +82-2-780-3132, Email: sungjin.chung@outlook.com
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Received: 13 September 2013 • Revised: 23 October 2013 • Accepted: 7 November 2013 |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits
unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Abstract |
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Tubulointerstitial nephritis is one of the common manifestations of immunoglobulin G (IgG)4-related disease; however, among
all cases of tubulointerstitial nephritis undergoing renal biopsies, IgG4-related tubulointerstitial nephritis seems to be relatively rare
because of its trivial urinary findings. A previously healthy 54-year-old man was referred to our clinic with a 4-week history of
lower leg purpura and renal dysfunction. A kidney biopsy was planned because of bilateral renomegaly, by imaging studies, and
elevated serum creatinine levels. Pathological findings in the kidney showed prominent infiltration of IgG4-postive plasma cells in
the tubulointerstitium, but not the glumeruli. A skin biopsy revealed leukocytoclastic vasculitis, accompanied by deposition of IgA
and C3 in the vascular wall, indicating Henoch-Schönlein purpura (HSP). Although cases of combined IgG4-related disease and
microvasculitis, including HSP, are extremely rare, the possibility of an association between two diseases deserves attention. |
| Key Words:
Immunoglobulin G4; Nephritis, Interstitial; Henoch-Schönlein purpura |
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