| Concurrence of Membranous Glomerulonephritis and Pulmonary Alveolar Proteinosis |
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Bongsoo Park1, Yang Wook Kim1, Hyunkuk Kim1, Taehoon No1, Mingyo Seo1, Yeon Mee Kim2, Kyubok Jin1 |
1Departments of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
2Departments of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea |
| 막성사구체신염과 동반된 폐포단백증 1예 |
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박봉수1, 김양욱1, 김현국1, 노태훈1, 서민교1, 김연미2, 진규복1 |
1인제대학교 의과대학 해운대백병원 내과
2인제대학교 의과대학 해운대백병원 병리과 |
Correspondence:
Kyubok Jin, Tel: +82-51-797-0606, Fax: +82-51-797-3282, Email: mdjin922@gmail.com
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Received: 16 August 2013 • Revised: 20 November 2013 • Accepted: 23 December 2013 |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Abstract |
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Membranous glomerulonephritis is one of the most common causes of nephrotic syndrome in adults. Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which abnormal accumulation of surfactant occurs within the alveoli. We describe a 61-year-old man with concurrent membranous glomerulonephritis and PAP, which is very rare; both are pathophysiologically related to an abnormal immune response. A patient came to hospital with leg edema but no respiratory symptoms. Chest X-ray and CT showed classical PAP findings, which are ground-glass opacities with interlobular septal thickening, in both lung fields. A bubbly whitish secretion retrieved via broncho-alveolar lavage showed neutrophils and lymphocytes as well as Periodic acid-Schiff-positive proteinaceous materials. A kidney biopsy revealed findings of membranous glomerulonephritis with irregular subepithelial deposits by electron microscopy. At 1 year after diagnosis, the membranous glomerulonephritis was well under control with steroids and mycophenolate mofetil but PAP became aggravated gradually and whole-lung lavage was needed. |
| Key Words:
Glomerulonephritis, membranous; Pulmonary alveolar proteinosis |
| 주제어:
막성사구체신염; 폐포단백증 |
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