Epidemiology and Etiology of Obstructive Sleep Apnea |
Dae Wui Yoon1, Jin Kwan Kim2, Chol Shin3 |
1Institute of Human Genomic Study, Korea University College of Medicine, Ansan, Korea 2Department of Biomedical Laboratory Science, Jungwon University College of Health Science, Goesan, Korea 3Division of Sleep, Pulmonary, and Critical Care Medicine, Department of Internal Medicine, Ansan Hospital, Korea University College of Medicine, Ansan, Korea |
폐쇄성 수면 무호흡증의 역학과 병인 |
윤대위1, 김진관2, 신철3 |
1고려대학교 의과대학 인간유전체 연구소 2중원대학교 의료보건대학 임상병리학교실 3고려대학교 의과대학 안산병원 호흡기내과 |
Correspondence:
Chol Shin, Tel: +82-31-412-5603, Fax: +82-31-412-5604, Email: chol-shin@korea.ac.kr |
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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Abstract |
Obstructive sleep apnea (OSA) is one of common sleep disorders in western countries, affecting 4% of males and 2% of females. It is characterized by repeated obstruction of the upper airway during sleep, leading to intermittent hypoxemia, sympathetic activation, and sleep fragmentation. OSA is an independent risk factor for a range of medical problems, including cardiovascular disease, diabetes, depression, and cognitive dysfunctions. The etiology of OSA is complex and incompletely understood, but recent studies have shown that the development of OSA depends on the structure of the airway anatomy, the responsiveness of the upper airway dilator muscle to stimulation, and the stability of the respiratory control system. This review details the epidemiological and experimental evidence surrounding the associations between OSA and chronic diseases. Recent findings on the etiology of OSA will also be discussed. |
Key Words:
Obstructive sleep apnea; Cardiovascular diseases; Etiology; Sleep disorders |
주제어:
폐쇄성 수면 무호흡증; 심혈관계 질환; 발병기전; 수면장애 |
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