| A Case of Disseminated Cryptococcosis Mimicking Lung Cancer and Prostate Cancer in an Immunocompetent Patient: A Review of the Literature |
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Yunkyoung Lee1, Ju Hyeon Kim1, Hyungil Seo1, Hyungchul Park1, Yeon-Mok Oh2, Sang-Do Lee2, Jae Seung Lee2 |
1Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Departments of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
| 폐암과 전립선 암으로 오인된 면역 정상 환자의 파종성 효모균증 1예 |
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이윤경1, 김주현1, 서형일1, 박형철1, 오연목2, 이상도2, 이재승2 |
1울산대학교 의과대학 서울아산병원 내과
2울산대학교 의과대학 서울아산병원 호흡기내과 |
Correspondence:
Jae Seung Lee, Tel: +82-2-3010-3994, Fax: +82-2-3010-6968, Email: jsdoc1186@daum.net
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Received: 29 July 2014 • Revised: 12 September 2014 • Accepted: 10 October 2014 |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Abstract |
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Cryptococcosis can occur in immunocompetent patients; in fact, it accounts for 20% of all cryptococcal infections. In immunocompetent patients, although clinical symptoms may not be obvious, cryptococcosis should be considered in the differential diagnosis for cancer and other diseases. We recently encountered a case of disseminated cryptococcosis involving the lung and prostate. A 71-year-old male patient was referred for evaluation of a large pleural effusion. He was a 40 pack-years ex-smoker, and showed no evidence of immunodeficiency. Chest computed tomography and positron emission tomography images suggested primary lung cancer with pleural metastases and prostate cancer. Tuberculous pleurisy was suspected due to a lymphocyte-dominant exudative pleural effusion and high level of adenosine deaminase. Prostate and bronchoscopic biopsies demonstrated chronic granulomatous inflammation, and periodic acid Schiff’s and Grocott’s methenamine silver staining confirmed cryptococcosis in both specimens. Antifungal therapy with fluconazole was started, and follow-up images showed complete resolution of the pleural effusion. |
| Key Words:
Immunocompetent; Cryptococcosis; Lung neoplasms; Prostatic neoplasms; Fluconazole |
| 주제어:
면역정상환자; 파종성 효모균증; 폐암; 전립선암; Fluconazole |
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