| The change of serum level of total antioxidant status and cytokine, and in-stent restenosis after supplementation of antioxidant |
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Hyung Geun Yoon, Duk Won Bang, Seung Hoon Park, Ji Hoon Ahn, John Seo, Yeo Joon Yoon, Min Su Hyon, Sung Koo Kim, Young Joo Kwon |
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Seoul National University College of Medicine |
| 항산화제 투여 후 총 항산화지수 및 사이토카인 변화와 스텐트 재협착에 미치는 영향 |
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윤형근, Duk Won Bang, Seung Hoon Park, Ji Hoon Ahn, John Seo, Yeo Joon Yoon, Min Su Hyon, Sung Koo Kim, Young Joo Kwon |
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| Abstract |
Background : Oxidative stress might be a role in atherosclerosis and increased intake of antioxidant appear to be protective and modify neointimal formation. An antioxidant and probucol prevents endothelial dysfunction and low density lipoprotein oxidation and also inhibits the secretion
of cytokine by macrophages. We aimed 1) to study the effects of antioxidant (Vitamin C, E and probucol) supplementation on serum level of antioxidant status (TAS), P-selectin, MCP-1, IL-6 and IL-10 and 2) to investigate the effects of antioxidant intake on in-stent restenosis.
Methods
: Total 90 patients were assigned to control or antioxidant group (probucol; 500 mg, vitamin C; 1,000 mg, vitamin E; 400 mg). We performed follow up coronary angiography in 35 patients of antioxidant group and 36 patients of control group after 6 months of coronary bare metal stent implantation. We counted the stenotic lesions more than 50% of implanted stent lumen as a restenosis by quantitative coronary angiography. The serum levels of total antioxidant status, P-selectin, MCP-1, IL-6 and IL-10 were measured.
Results
: The serum levels of total antioxidant status was not elevated in antioxidant group. Antioxidant supplementation did not change the serum levels of P-selectin, MCP-1, IL-6 and IL-10. The 6-month angiographic in-stent restenosis rate was 27% versus 30% (p=NS) with an associated late loss of 0.76¡¾1.01 mm versus 0.91¡¾1.00 mm (p=NS) for antioxidant group and control group. The serum levels of total antioxidant status did not correlate with the restenosis or late loss after stent implantation.
Conclusions
: Vitamin C, E and probucol did not elevate the serum level of antioxidant status and could not prevent in-stent restenosis after bare metal stent implantation.
Key Words : Antioxidants, Cytokines, Coronary restenosis |
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