| Two cases of colonic mucinous adenocarcinoma originating from serrated adenomas |
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이화여자대학교 의과대학 내과학교실 |
| 증례 : 거치상 선종에서 발생한 대장의 점액성 선암 2예 |
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정효진&#;김태오&#;김광하&#;허 정&#;강대환&#;송근암&#;조 몽, , , , , , |
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Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea |
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| Abstract |
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Serrated adenoma has been proposed to be a distinct entity among the colonic neoplasms. Progression to frank carcinoma has been suggested in individual cases, but the prevalence of the carcinomas that originated from serrated adenomas and their clinico-pathological characteristics are not known. The serrated pathway encompasses hyperplastic aberrant crypt foci, hyperplastic polyps, mixed polyps and serrated adenoma, and it is increasingly being associated with genetic alterations, including DNA microsatellite instability and KRAS mutation. The importance of the serrated pathway has been underestimated in terms of its frequency and potential for rapid progression.
We report here on two cases of colonic mucinous adenocarcinoma originating from serrated adenomas.(Korean J Med 71:S929-S933, 2006) |
| Key Words:
Serrated adenoma, Colonic adenocarcinoma |
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