| Severe hypokalemia and status epilepticus associated with theophylline toxicity |
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Hyun Sup Cho, Dong Wook Kim, Dong-Won Lee, Eun Young Jung, Se-Ho Chang, Dong Jun Park |
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Cardiology Division, Department of Internal Medicine, Yeungnam University Hospital1 |
| 증례 : 테오필린 독성에 의해 발생한 심한 저칼륨혈증과 간질 중첩증 |
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조현섭&#;김동욱&#;이동원&#;정은영&#;장세호&#;박동준, Dong Wook Kim, Dong-Won Lee, Eun Young Jung, Se-Ho Chang, Dong Jun Park |
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| Abstract |
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Theophylline can induce severe metabolic complications, including hypokalemia, seizure and cardiac arrhythmias.
However, clinicians can fail to identify this drug as the cause of these complications. We describe here a case for which
the patient's theophylline toxicity went unrecognized over a period of several days after the complications developed.
An 84-year-old man who was without any previous history of seizure was admitted to our hospital because of two
episodes of generalized tonic-clonic seizure. His initial potassium level was 1.64 mmol/L. The electroencephalogram
showed frequent, single or sequential, sharp and slow waves of high amplitudes on the right fronto-polar area, which
was compatible with focal seizure. With giving only 100 mmol of K+ replacement over the three days, the serum
potassium level increased to 3.5 mmol/L. His generalized tonic clonic seizure was controlled by lorazepam and phenytoin.
We obtained the history of theophylline medication from his son on the 5th hospital day. At that time, the serum
theophylline level was 9.18 ug/mL.(Korean J Med 73:S1008-S1011, 2007) |
| Key Words:
Theophylline, Hypokalemia, Seizure |
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