| The clinical feature and pathogenesis of gastroduodenal lesion in patients with scrub typhus |
|
Ji Young Park, Min Sun Cho, Ki Nam Shim, You Jin Lee, BA., Hee Jung Choi |
|
전남대학교병원 심장센터, 간호부, 전남대학교 심혈관계 특성화 사업단 |
| 원저 : 쯔쯔가무시병에서 상부위장관 병변의 임상 특징과 발생기전에 관한 연구 |
|
박지영, 조민선, 심기남, 이유진, 최희정, Hee Jung Choi |
|
|
|
|
|
|
| Abstract |
|
Background/Aims : The aim of the study was to investigate the gastric involvement of Orientia tsutsugamushi and the relationship between the clinical features and gastritis in patients with scrub typhus.
Methods : The study included 98 patients who had been diagnosed with scrub typhus between January 2003 and December 2006. Sixteen patients were selected to undergo gastroduodenoscopy with endoscopic biopsy for molecular study. The clinical severity index score (CSIS) was evaluated. Rickettsial DNA was amplified using the paraffin- embedded biopsy tissue by performing nested PCR. The expressions of ICAM-1 and VCAM-1 were investigated by immunohistochemistry to evaluate their roles in the pathogenesis of scrub typhus.
Results : The endoscopic findings were gastritis (n=1), erosion (n=4) and ulcer (n=11). The average CSIS was 3.65¡¾1.09. Four cases of nested PCR of the 16 gastric mucosal biopsies were positive. The gastric samples that were taken earlier after therapy tended to be PCR-positive (2.00¡¾00 days vs. 3.83¡¾1.27 days, p<0.001). There was no difference of the clinical features and the CSISs between the PCR-positive and PCR-negative patients. The biopsied tissue revealed no vasculitis findings. Staining for ICAM-1 was more expressed in the scrub typhus group as compared with the normal control group. Staining for VCAM-1 was sporadically expressed in the scrub typhus group and normal control group. In comparison with the patients with Helicobacter pylori-associated gastritis, the immunohistochemical staining showed no difference of expression in the patients with O. tsutsugamushi-infected gastritis.
Conclusions : The gastritis seen in scrub typhus patients could be typhus that is related to the direct involvement of O. tsutsugamushi. The increased expression of ICAM-1 may be related with gastric mucosal endothelial injury due to direct infection. |
| Key Words:
Lupus nephritis; Mycophenolate mofetil; Cyclophosphamide |
|
PDF Links
Full text via DOI
Download Citation
