| A case of valproic acid-induced hyperammonemic encephalopathy |
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Jong Hak Choi, Jung Eun Kim, Kwang Sun Lee, Chae Heo, Taek Kyun Nam, Jeong Wook Kim, Seung Won Park |
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성균관대학교 의과대학 삼성서울병원 심장혈관센터 순환기내과 |
| 정상 간기능을 보이는 발프로산 유발 고암모니아혈증성 뇌병증 1예 |
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최종학, 김정은, 이광선, 허 채, 남택균, 김정욱, 박승원 |
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| Abstract |
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Valproic acid is an effective anticonvulsant used in neurology and psychiatry. Valproic acid-induced hyperammonemic encephalopathy is an unusual complication characterized by a decreasing level of consciousness, the development of progressive confusional states and, sometimes, a coexisting increase in the frequency of seizures after the onset of valproic acid treatment. It can lead to death, but can be reversed if a swift diagnosis is made. We report the case of a 58-year-old woman with an intracerebral hemorrhage and normal liver function who presented with valproic acid-induced hyperammonemic encephalopathy. After valproic acid treatment, she developed encephalopathy and became comatose, with seizures and a markedly elevated serum ammonia level. Her neurologic manifestations and hyperammonemia improved after discontinuing the valproic acid. (Korean J Med 75:680-684, 2008) |
| Key Words:
Valproic acid; Hyperammonemia; Adverse effect; Seizure |
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