A Case of Crescentic Glomerulonephritis and Marginal Zone B-cell Lymphoma

Yi, YongJin; Ryu, HyunJin; Park, Ji In; Lee, Jung Pyo; Lim, Chun Soo; Moon, Kyung-Chul; Oh, Yun Kyu

doi:2014.87.5.609

Korean J Med > Volume 87(5); 2014 > Article

Case Report

The Korean Journal of Medicine 2014;87(5):609-614.
Published online November 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.87.5.609

A Case of Crescentic Glomerulonephritis and Marginal Zone B-cell Lymphoma

YongJin Yi², HyunJin Ryu², Ji In Park², Jung Pyo Lee^1,2, Chun Soo Lim^1,2, Kyung-Chul Moon³, Yun Kyu Oh^1,2

¹Department of Internal Medicine, Seoul National University, Boramae Medical Center, Seoul, Korea
²Departments of Internal Medicine, Seoul National University, Boramae Medical Center, Seoul; Departments of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
³Departments of Pathology, Seoul National University College of Medicine, Seoul, Korea

변연대 B세포 림프종에 동반된 초승달사구체신염 1예

이용진², 류현진², 박지인², 이정표^1,2, 임춘수^1,2, 문경철³, 오윤규^1,2

^¹서울대학교 보라매병원 내과
^²서울대학교 의과대학 내과학교실
^³서울대학교 의과대학 병리학교실

Correspondence:
Yun Kyu Oh, Tel: +82-2-870-2219, Fax: +82-2-870-3863, Email: yoonkyu@snu.ac.kr

Received: 31 July 2013 • Revised: 18 October 2013 • Accepted: 25 November 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/bync/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Secondary rapidly progressive glomerulonephritis (RPGN) can be caused by many diseases and conditions, including vasculitis, systemic rheumatic diseases, infections, drugs and malignancies. Among the secondary RPGNs, malignancy-associated RPGN is extremely rare and causes renal function deterioration within several weeks to months. Thus, timely immunosuppressant therapy can improve renal outcome. Herein, we describe a case of RPGN detected simultaneously with marginal zone B-cell lymphoma. An 82-year-old male patient, who presented generalized edema and oliguria, was diagnosed with crescentic glomerulonephritis and marginal B-cell lymphoma. After the patient was given methylprednisolone pulse therapy, renal function was restored and hemodialysis was successfully discontinued without complications.

Key Words: Crescentic glomerulonephritis; Rapidly progressive glomerulonephritis; Marginal zone B-cell lymphoma

주제어: 초승달사구체신염; 급속진행사구체신염; 변연대 B세포 림프종