Blood Tests for the Diagnosis of Adrenal Diseases

Seon-Ah Cha; Sung-Dae Moon

doi:10.3904/kjm.2021.96.2.152

Korean J Med > Volume 96(2); 2021 > Article

부신 질환의 진단을 위한 혈액 검사

Erratum

Korean J Med 2021;96(2):152-154.

DOI: https://doi.org/10.3904/kjm.2021.96.2.152

부신 질환의 진단을 위한 혈액 검사

차선아¹, 문성대²

¹가톨릭대학교 의과대학 성빈센트병원 내분비내과

²가톨릭대학교 의과대학 인천성모병원 내분비내과

Blood Tests for the Diagnosis of Adrenal Diseases

Seon-Ah Cha¹, Sung-Dae Moon²

¹Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea

²Division of Endocrinology and Metabolism, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea

Published online 2021. 4. 1

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Korean J Med 2018;93:532-537. https://doi.org/10.3904/kjm.2018.93.6.532

다음과 같이 Table 내 오류가 있어 수정합니다.

Table 1.

Drugs that may affect the metabolism of plasma cortisol, aldosterone, renin, and catecholamines

Adrenal hormone	Drug group	Drugs	Recommended withdrawal time
Plasma cortisol↓^a after overnight DST	Drugs that increase metabolism by inducing CYP3A4	Phenytoin, barbiturates, carbamazepine, rifampicin, alcohol, estrogen, mitotane	2 weeks [7]
Plasma cortisol↑^b after overnight DST	Drugs that decrease metabolism by inhibiting CYP3A4	Itraconazole, ritonavir, diltiazem, cimetidine	2 weeks
PAC/PRA ratio↓^a [19]	Angiotensin-converting enzyme inhibitors	Captopril, enalapril, fosinopril, lisinopril, ramipril	2 weeks
	Angiotensin receptor blockers	Losartan, valsartan, irbesartan, candesartan, telmisartan, eprosartan, olmesartan, fimasartan	2 weeks
	Dihydropyridine calcium channel blockers	Nifedipine, amlodipine	2 weeks
	Mineralocorticoid antagonists	Spironolactone, eplerenone	4 weeks
	Diuretics	Hydrochlorothiazide, furosemide, torsemide	4 weeks
PAC/PRA ratio↑^b [19]	β-blockers	Atenolol, bisoprolol, metoprolol, nebivolol, esmolol, propranolol, carvedilol, labetalol, nadolol	2 weeks
	NSAIDs	Ibuprofen, dexibuprofen, naproxen, fenoprofen, ketoprofen, loxoprofen, ketorolac, aceclofenac, diclofenac, piroxicam, meloxicam	2 weeks
	Renin inhibitor	Aliskiren	2 weeks
	Central agonists	Clonidine, α-methyldopa	2 weeks
Plasma catecholamines [20]	Alpha-blockers	Phenoxybenzamine, doxazosin	15 days
	Tricyclic antidepressants	Amitriptyline, imipramine, nortriptyline	3 days
	Antihistamine	Promethazine	3 days
	Sympathomimetics	Salbutamol, terbutaline, bambuterol	3 days
	Antipsychotics	Chlorpromazine, haloperidol, perphenazine, amisulpride, clozapine, olanzapine, quetiapine, risperidone	10 days-1 month for depot

DST, dexamethasone suppression test; CYP3A4, cytochrome P450 3A4; PAC, plasma aldosterone concentration; PRA, plasma renin activity; NSAIDs, nonsteroidal anti-inflammatory drugs.

^a Possibility of false-negative results.

^b Possibility of false-positive results.

Table 1.

Drugs that may affect the metabolism of plasma cortisol, aldosterone, renin, and catecholamines

Adrenal hormone	Drug group	Drugs	Recommended withdrawal time
Plasma cortisol↑after overnight DST	Drugs that increase metabolism by inducing CYP3A4	Phenytoin, barbiturate, carbamazepine, rifampicin, alcohol, mitotane	2 weeks [7]
Plasma cortisol↓after overnight DST	Drugs that decrease metabolism by inhibiting CYP3A4	Itraconazole, ritonavir, diltiazem, cimetidine	2 weeks
PAC/PRA ratio ↓[8]	Angiotensin-converting enzyme inhibitor	Captopril, Enalapril, Fosinopril, Lisinopril, Ramipril	2 weeks
	Angiotensin receptor blocker	Losartan, Valsartan, Irbesartan, Candesartan, Telmisartan, E prosartan, Olmesartan, Fimasartan	2 weeks
	Dihydropyridine calcium channel blocker	Nifedipine, Amlodipine	2 weeks
	Mineralocorticoid antagonist	Spironolactone, Eplerenone	4 weeks
	Diuretics	Hydrochlorothiazide, Furosemide, Torsemide	4 weeks
PAC/PRA ratio↑[8]	β-blockers	Atenolol, Bisoprolol, Metoprolol, Nebivolol, Esmolol, Propranolol, Carvedilol, Labetalol, Nadolol	2 weeks
	NSAIDs	Ibuprofen, Dexibuprofen, Naproxen, Fenoprofen, Ketoprofen, Loxoprofen, Ketorolac, Aceclofenac, Diclofenac, Piroxicam, Meloxicam	2 weeks
	renin inhibitor	Aliskiren	2 weeks
	central agonist	clonidine, α-methyldopa	2 weeks
Plasma catecholamines [9]	Alpha-blocker	Phenoxybenzamine, Doxazosin	15 days
	Tricyclic antidepressant	Amitriptyline, Imipramine, Nortriptyline	3 days
	Antihistamine	Promethazine	3 days
	Sympathomimetic	Salbutamol, Terbutaline, Bambuterol,	3 days
	Antipsychotic	Chlorpromazine, Haloperidol, Perphenazine, Amisulpride, Clozapine, Olanzapine, Quetiapine, Risperidone	10 days-1 month for depot

DST, dexamethasone suppression test; CYP3A4, cytochrome P450 3A4; PAC, plasma aldosterone concentration; PRA, plasma renin activity; NSAIDs, nonsteroidal anti-inflammatory drugs.

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