| Clonal Hematopoiesis in Human Disease: An Essential Immunologic Phenomenon in Aging Populations |
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Youngil Koh |
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Division of Hemato Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea |
| 클론성 조혈증에 대한 이해: 고령화 시대에 꼭 알아야 하는 것 |
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고영일 |
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서울대학교병원 혈액종양내과 |
Correspondence:
Youngil Koh, Tel: +82-2-2072-7217, Fax: +82-2-2072-3379, Email: go01@snu.ac.kr
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Received: 28 April 2025 • Revised: 30 May 2025 • Accepted: 12 June 2025 |
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| Abstract |
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Clonal hematopoiesis denotes a condition involving acquired genetic mutations in hematopoietic stem cells, and is recognized as precancerous lesion for hematologic malignancy (e.g., myelodysplastic syndrome or acute myeloid leukemia). Recent scientific advances indicate that clonal hematopoiesis rather represents an immunologic alteration of myeloid lineage-derived cells upon genetic mutations that can affect the course of various chronic diseases. The role of clonal hematopoiesis in chronic disease has been actively studied in cardiovascular and degenerative brain diseases as well as solid tumors. These discoveries consistently imply that the role of clonal hematopoiesis differs mutated gene- and involved target organ-dependently. Mutated immune cells infiltrate into the diseased organ to affect the disease. |
| Key Words:
Clonal hematopoiesis; Chronic disease; Hematologic neoplasms; Clonal evolution |
| 주제어:
클론성 조혈증; 만성 질환; 혈액암; 클론의 진화 |
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