Korean J Med > Volume 100(5); 2025 > Article
Hemato-oncology
The Korean Journal of Medicine 2025;100(5):219-224.
Published online October 1, 2025.
DOI: https://doi.org/10.3904/kjm.2025.100.5.219   
Tailored Strategies for Applying Large Language Models in Clinical Settings and Addressing Data Security Challenges
Tae Joon Jun
Department of Information Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
의료 현장 맞춤형 거대 언어 모델 활용 전략과 데이터 보안 대응 방안 탐색
전태준
울산대학교 의과대학 서울아산병원 정보의학과
Correspondence: 
Tae Joon Jun, Tel: +82-2-3010-8642, Fax: +82-2-3010-8642, Email: taejoon@amc.seoul.kr
Received: 27 May 2025   • Revised: 24 July 2025   • Accepted: 28 July 2025
Abstract
Since the advent of ChatGPT in 2022, large language models (LLMs) have rapidly evolved, and their clinical applications are currently being explored. This paper introduces three practical strategies for applying LLMs in healthcare settings: text-to-text, any-to-text, and retrieval-augmented generation. Each strategy is described using real-world examples and analyzed for potential data security risks. Although LLMs offer promising efficiency and performance benefits, they also pose new challenges regarding privacy and information leakage, particularly when trained using sensitive patient data. We propose tailored learning and governance approaches to mitigate such risks, emphasizing the necessity of de-identification techniques and robust guardrails for ensuring safe and effective deployment in clinical settings.
Key Words: Large language models; Computer security; Generative artificial intelligence
주제어: 거대 언어 모델; 컴퓨터 보안; 생성형 인공지능


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