| From Genes to Clinics: The Genomic Paradigm Shift in Chronic Kidney Disease Diagnosis and Care |
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Woo Sik Yang1,2, Ho Sik Shin1,2 |
1Renal Division, Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea
2Transplantation Research Institute, Kosin University College of Medicine, Busan, Korea |
| 유전자에서 임상까지: 만성 콩팥병 진단과 치료에서의 유전체학적 패러다임 전환 |
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양우식1,2, 신호식1,2 |
1고신대학교 의과대학 고신대학교복음병원 신장내과
2고신대학교 의과대학 장기이식연구소 |
Correspondence:
Ho Sik Shin, Tel: +82-51-990-6108, Fax: +82-51-248-5686, Email: 67920@naver.com
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Received: 24 October 2025 • Revised: 18 November 2025 • Accepted: 28 November 2025 |
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| Abstract |
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Chronic kidney disease (CKD) is undergoing a paradigm shift as genetic insights have reshaped its diagnosis and management. Rare monogenic variants explain a growing number of early onset and familial cases, while polygenic risk scores offer new tools for risk stratification. Emerging research, especially from Korean cohorts, has revealed modifiable gene-environment interactions and integrates genomics with metabolomics to uncover disease-specific pathways. Genetic testing plays a pivotal role in clinical reclassification and therapeutic decision-making. With the expansion of kidney genetics clinics, generalists and specialists must adapt to this era of precision. The journey from genes to clinics is no longer conceptual; rather, it redefines CKD care. |
| Key Words:
Renal insufficiency, chronic; Genes; Clinics |
| 주제어:
만성 콩팥병; 유전; 임상 |
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