| An 87-Year-Old Woman with Rapidly Progressive Epidermal Detachment and Mucosal Involvement |
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Ga-Young Ban |
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Department of Pulmonary, Allergy, and Critical Care Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea |
| 급속히 진행하는 피부 박리와 점막 병변을 보인 87세 여자 |
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반가영 |
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한림대학교 의과대학 강동성심병원 호흡기·알레르기내과 |
Correspondence:
Ga-Young Ban, Tel: +82-2-2152-1372, Fax: +82-2-477-6925, Email: rkduddle@hanmail.net
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Received: 21 May 2026 • Revised: 23 July 2026 • Accepted: 30 July 2026 |
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| Abstract |
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions characterized by extensive epidermal necrosis and mucosal involvement. Allopurinol is a major causative drug in Asian populations and is strongly associated with HLA-B*58:01. Early recognition of clinical warning signs, including fever, painful skin lesions, mucosal involvement, and rapidly progressive epidermal detachment, is essential because delayed diagnosis may increase mortality. This article reviews the clinical manifestations, diagnostic approach, HLA associations, and current treatment strategies of SJS/TEN, illus-trated by a case of allopurinol-induced SJS/TEN overlap in an HLA-B*58:01-negative older patient. |
| Key Words:
Stevens-Johnson syndrome; Toxic epidermal necrolysis; Allopurinol; HLA-B*58:01; Severe cutaneous adverse reaction |
| 주제어:
스티븐스-존슨 증 후군; 독성 표피 괴사 용해; 알로퓨리놀; HLA-B*58:01; 중증 피부 약물 이상 반응 |
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