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Review
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Korean J Med. 2006;71(1):147-147.
- Discontinuation of statin therapy and the follow-up lipoprotein profile pattern
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Min-Kyung Kim, Min-Suk Kim, Kyung-Woo Park, Sang-Hyun Kim, Ju-Hee Jo, Myung-A Kim, Hyo-Soo Kim, Dae-Won Sohn, Byung-Hee Oh, Young-Bae Park, Yoon-Sik Choi
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- Discontinuation of statin therapy and the follow-up lipoprotein profile pattern
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전남대학교 의과대학 내과학교실
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- Abstract
- Objective : This study was designed to assess the characteristics and lipoprotein profile changes of patients, who have
discontinued statin therapy. Methods : Total 72 (male 43%) patients were enrolled. Data of body mass indexes (BMIs),
coexistence of diabetes mellitus (DM), hypertension (HTN), coronary artery disease (CAD) and cerebrovascular accident (CVA)
were obtained from the charts. Laboratory data of lipoprotein levels were obtained from computer-based chart reviews. Results
: Average age was 63.3 years. The prevalence of diabetes mellitus was 28%, hypertension was 72% and coronary artery disease
was 42%. Average fasting lipoprotein levels before ceasing statin were: total cholesterol (TC) = 164.3 mg/dL, triglycerides (TG)
= 172.3 mg/dL, high-density lipoprotein cholesterol (HDL-C) = 56 mg/dL and low-density lipoprotein cholesterol (LDL-C) = 94.9
mg/dL. The fasting lipoprotein levels after 2 to3 months from ceasing statin therapy were: TC = 147.3 mg/dL, TG = 139.4
mg/dL, HDL-C = 26.5 mg/dL and LDL-C = 126.2 mg/dL. And 4 to 6 months after ceasing statin, the levels were: TC = 157.3
mg/dL, TG = 138.8 mg/dL, HDL-C = 26.7 mg/dL and LDL-C = 134.6 mg/dL. 75% of patients showed their HDL-C level lower
than 40mg/dL(45mg/dL for female) after 2 to 3 months of discontinuation and 84% of patients showed low HDL-C level after
4 to 6 months of discontinuation. Conclusion : After statin therapy was stopped, it s not very long time needed the patients
TC and LDL-C level elevation and/or HDL-C level decrease.
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