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Review
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Korean J Med. 2006;71(1):157-157.
- The relationship between matrix metalloproteinase 1 gene polymorphism and myocardial infarction in Korean subjects
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- The relationship between matrix metalloproteinase 1 gene polymorphism and myocardial infarction in Korean subjects
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- The matrix metalloproteinases (MMPs) are a family of enzymes that are important in the degradation of collagen fibers and other matrix proteins. MMP-1 expression, which
plays an important role in the degradation of collagen types I, II, and III, is significantly increased in vulnerable atherosclerotic plaques with a thin fibrous cap overlaying
a large lipid core, compared with stable atherosclerotic plaques with a thick fibrous cap. We investigated whether the polymorphisms in the gene encoding MMP-1 had
merit as predictive factor of myocardial infarction. Analyses of 1G/2G polymorphisms at position -1607 in the promoter region of MMP-1 gene in relation to MI risk were
performed. Among patients with ischemic heart disease, subjects carrying the homozygous 2G/2G genotype had a higher risk of myocardial infarction compared with
subjects with other genotypes (adjusted OR: 2.930; 95% CI: 1.58?3.27), adjusted for age and gender. Furthermore, when compared with control group, subjects carrying
the homozygous 2G/2G genotype had a higher risk of myocardial infarction (adjusted OR: 1.457; 95% CI: 0.701?3.029). These findings suggest that the presence of 2G
polymorphism at the MMP1 promoter is associated with the development and progression of myocardial infarction, especially in people who already had an ischemic heart
disease. We speculate that more transcriptionally active 2G allele of the MMP-1 promote plaque instability and rupture and precipitate MI in 2G/2G genotype. In conclusion,
this study shows that 2G/2G genotype at position -1607 in promoter region of MMP-1 may contribute to role as predictive factor of acute myocardial infarction.
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