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Review
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Korean J Med. 2006;71(1):179-179.
- Assessment of the Biologic Markers Prostatic Specific Antigen (PSA), Prostate Specific Membrane Antigen (PSMA) and Human Epidermal Receptor-2 (HER-2) in Prostate Cancer after Surgery.
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In Gyu Hwang, Chul Won Jung, Jeeyun Lee, Byeong-Bae Park, Yong Sang Hong, Sarah Park, Sang Cheol Lee, Sang Yong Song, Won Seog Kim, Ho Yeong Lim, Han Yong Choi
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- Assessment of the Biologic Markers Prostatic Specific Antigen (PSA), Prostate Specific Membrane Antigen (PSMA) and Human Epidermal Receptor-2 (HER-2) in Prostate Cancer after Surgery.
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이화여자대학교 의과대학 내과학교실, 호흡기내과
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- Abstract
- ABSTRACT The use of molecular markers to supplement clinical information concerning the biologic aggressiveness of prostate
carcinoma may allow better prediction of the outcome of individual patients. This study was designed to evaluate the potential
of the cellular markers PSA, PAP, PSMA, and HER-2 as adjuncts to the commonly available parameters of tumor grade, stage,
serum PSA to predict the recurrence after radical prostatectomy. Tissue microarrays were constructed from the specimens of
prostate carcinoma from 86 men who underwent radical prostatectomy for prostate cancer. The immunostainings for PSA, PAP,
PSMA, HER-2 were performed. Expressions of PSA, PAP, PSMA, and HER-2 were increased in 98% (84/86), 99% (85/86), 72%
(48/67), and 78% (52/67) of the tumor specimens, respectively. No variables tested were associated with clinical or biochemical
relapse after prostatectomy. The PSA expression was significantly correlated with high tumor volume (p=0.001) and large tumor
size (p=0.007). The relevance of the markers, PSA, PAP, PSMA, or HER-2 to the recurrence of prostate cancer seems to be low
based on the study. Key Words: Prostate; Prostatic Specific Antigen; Prostate Specific Membrane Antigen; Human Epidermal
Receptor-2
Keywords :
