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Review
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Korean J Med. 2006;71(1):179-179.
- Clinicopathologic Characteristics and Prognostic Value of Triple negativity in Node-negative Early Breast cancer
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Ji-Young Rhee, In-Sil Choi, Byung-Soo Kim, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Tae-You Kim, In Ae Park, Yung-Jue Bang
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- Clinicopathologic Characteristics and Prognostic Value of Triple negativity in Node-negative Early Breast cancer
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, , , , , , , ,
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중앙대학교 병원 내과학교실, 비뇨기과 교실, Cell genomics
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- Abstract
- Background : Triple negative (TN) basal-like breast cancer (negative for ER, PR, Her2/neu) represents different phenotype
with unique clinical and pathologic features. The purpose of this study was to determine the clinicopathologic characteristics and
the prognostic significance of triple negativity in node negative early breast cancer in single institute. Methods : 648 patients
with node-negative early breast cancer among a cohort of 1326 women who underwent breast cancer surgery between January
2000 and June 2003 at the Seoul National University Hospital were reviewed retrospectively. Clinicopathologic variables were
analyzed including age, T stage, hormone receptor (HR), HER-2, endovascular or lymphatic tumor emboli, nuclear grade,
histologic grade, p53, bcl-2, Ki-67,EGFR and relapse free survival (RFS) Result: The median age was 47 year old (range: 22-84
year old). 273 patients (36.2%) received breast conserving surgery followed by adjuvant radiotherapy. 394 patients (60.8%)
received adjuvant chemotherapy (CMF:77.9%, AC:10.4%, FAC: 6.1%, others: 4.6%, unknown:1%) The median follow-up duration
was 48.5 months. 52 patients (8%) were relapsed. (Locoregional relapse: 25%, distant metastasis :46.1%, locoregional relapse and
distant metastasis: 5.8% contralateral breast:23.1%). Patients with triple negativity were 136 (20.9 % of node negative patients).
They showed more aggressive clinicopathologic features than other patient populations. (more younger than 35 years old,
p=0.007, higher histologic grade, p<0.001, more positive for p-53 (p=0.006), Ki-67 (p<0.001) and EGFR (p=0.001), more negative
for Bcl-2 (p<0.001)) And RFS of patients with triple negativity was significantly shorter than other patient populations (median
RFS : 45.6 months vs. 47.65 months, p<0.0001). In addition, Age<35 years(p=0.001), presence of endovascular or lymphatic tumor
emboli (p=0.030), and triple negativity(p=0.001) were significant prognostic factors for RFS on multivariate analysis. Conclusion
: Patients with triple negativity in node-negative early breast cancer show more aggressive clinicopathological features and
shorter RFS
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