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Review
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Korean J Med. 2006;71(1):182-182.
- Clinicopathologic features and outcome of hepatic resection for liver metastasis from gastric cancer
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- Clinicopathologic features and outcome of hepatic resection for liver metastasis from gastric cancer
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Background : The efficacy of surgical resection of liver metastasis from gastric cancer is not well established. Objective : The
aim of this study is to assess the beneficial effect of hepatic resection in patients with hepatic metastasis from gastric carcinoma
and to evaluate the prognostic factors affecting the survival. Patients and Methods : Among 10261 patients who were diagnosed
gastric adenocarcinoma at Severance Hospital of Yonsei University College of Medicine from January 1995 to October 2005, we
reviewed the records of patients with metastatic hepatic tumors from gastric cancer who underwent either hepatic or gastric
surgical resections. Hepatic resection was indicated only in patients with hepatic metastasis without peritoneal dissemination or
any other distant metastasis who seemed to be resectable completely in preoperative evaluation. Intraoperative radiofrequency
ablation was performed in patients who deemed to have unresectable hepatic disease based on tumor multifocality, tumor
proximity to major vascular structures precluding a margin-negative resection, or the presence of severe cirrhosis with
functional hepatic reserve inadequate to tolerate the necessary hepatic resection. The clinicopathologic features and survivals
were analyzed using the SPSS software, version 12 (SPSS Inc, Chicago, IL, USA). Results : 1015 patients had liver metastasis
and 43 hepatic resections were performed for hepatic metastasis from gastric adenocarcinoma with curative intent. Of these, 22
patients (0.21%) had complete resection of their primary gastric cancer with liver metastasis. The overall 1-year, 3-year, and
5-year survival rates of patients with curative-intent hepatic resection were 76.5%, 32.7%, and 17.4%, respectively, and 3 patients
survived more than 7 years. The number of liver metastasis (solitary or multiple) was the only significant prognostic factor
according to both univariate and multivariate analyses. Conclusions : Surgical resection for liver metastasis of gastric cancer that
complete resection seems to be feasible may be beneficial. Moreover, surgical resection should be considered for patients with
a solitary hepatic tumors from gastric cancer as one of the treatment options.
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