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Review
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Korean J Med. 2006;71(1):194-194.
- Anti-CCP Antibody Levels Are Associated with PADI4 Haplotypes and HLA-DRB1 Shared Epitope Alleles in Non-erosive and Erosive RA, Respectively
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Chan-Bum Choi, Seongwon Cha, Tae-Un Han, Changsoo Paul Kang, Changwon Kang, Sang-Cheol Bae
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- Anti-CCP Antibody Levels Are Associated with PADI4 Haplotypes and HLA-DRB1 Shared Epitope Alleles in Non-erosive and Erosive RA, Respectively
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, , , , ,
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아주대학교 의과대학 호흡기내과
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- Abstract
- Objective. Anti-cyclic citrullinated peptide antibodies (anti-CCPs) are rheumatoid arthritis (RA)-specific serologic markers. RA
susceptibility has been associated with HLA-DRB1 shared epitope (SE) alleles and single-nucleotide polymorphism (SNP)
haplotypes in the peptidylarginine deiminase 4 (PADI4) gene. Here, we tested whether anti-CCP levels are associated with
PADI4 haplotypes and/or SE alleles in Korean RA patients. Methods. Three nonsynonymous SNPs in PADI4 (padi4_89, padi4_90
and padi4_92) and SE alleles were genotyped, and serum anti-CCP levels were measured in 311 Korean patients having
non-erosive or erosive RA. The relationships between anti-CCP levels and PADI4 haplotypes and/or SE were examined using
Student's t-tests. Results. Anti-CCP levels were significantly higher in PADI4 RA risk haplotype carriers versus non-carriers
among anti-CCP-positive patients having non-erosive RA (P = 0.022, 2.0-fold in mean level) and among those afflicted with RA
for 40 months or less (P = 0.019, 2.1-fold), but not among patients having erosive RA or afflicted longer. In contrast, the levels
were significantly higher in SE carriers versus non-carriers among patients with erosive RA (P = 0.000022, 2.5-fold) and among
those afflicted with RA for 179 months or more (P = 0.0014, 2.8-fold), but not among patients having non-erosive RA or afflicted
shorter. Conclusion. The PADI4 RA risk haplotype is associated with increased anti-CCP levels in non-erosive but not in erosive
RA patients, and PADI4 may play a role in early RA. In contrast, SE alleles are associated with increased anti-CCP levels in
erosive but not in non-erosive RA patients, and SE may play a role in late RA.
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