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Review
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Korean J Med. 2006;71(1):195-195.
- PADI4 polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis.
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- PADI4 polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis.
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- We conducted a comprehensive meta-analysis with all available data on the association of allele (allele 2 vs 1) and genotype
(2/2 vs 1/1, 2/2 vs 1/2, and 1/2 vs 1/1) of the whether peptidylarginine deiminases 4 (PADI4) polymorphisms with RA overall
and in each ethnic population to explore whether PADI4 polymorphisms confer susceptibility to RA.. Nine comparisons, 3 Asian
and 6 European, from 8 studies were included in this meta-analysis. Overall meta-analysis shows a significant association of
PADI4_94, 104 and 90 with RA (OR = 1.20, 1.17, 1.35, p = 0.001, < 0.0001, 0.006, respectively). There was a significant association
with all of the PADI4 polymorphisms with RA in people of Asian descent. However, there was no significant association of
PADI4 polymorphisms with RA in people of European descent, except for PADI4_94. The presence of 2/2 genotype of the
PADI4_94 significantly increased the risk for RA in European populations (OR = 2.10, 95% CI, 1.66 - 2.66, p < 0.0001) without
between-study heterogeneity (I2 = 44.3, p = 0.15). This meta-analysis demonstrates that the PADI4_94 polymorphisms may
represent a significant risk factor for RA in Asians and Europeans and play a larger role in susceptibility to RA in Asian than
in European populations.
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