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Review
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Korean J Med. 2006;71(1):197-197.
- Clinical characteristics of post-surgical gout
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Eun Ha Kang, Hee Jung Ryu, Jung Hwa Lee, Byung Yong Choi, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Yeong Wook Song.
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- Clinical characteristics of post-surgical gout
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울산대학교 의과대학 서울아산병원 호흡기내과
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- Abstract
- Introduction : Surgery has been considered as a risk factor for gout attack because it requires conditions that are prone to
induce gout attack; peri-surgical starvation and catabolic status induced by surgical procedure. We investigated the clinical
characteristics and risk factors for post-surgical gout attack. Methods : Medical charts were reviewed for 72 patients who
suffered gout attack after surgery and for 67 patients who had previous gout history but did not experience attacks after surgery.
Gout was proven by observing mono-sodium urate crystal in synovial fluid from affected joints in these patients. Results :
Among patients who suffered post-surgical attack, 93.1% (67/72) had previous gout history. There was no statistically significant
difference between patients who suffered post-surgical attack and gout patients who did not develop post-surgical attacks in
terms of age, gender distribution, body mass index, prevalence of diabetes mellitus, hypertension, dyslipidemia and renal
impairment of serum creatinine > 1.4 mg/dL. However, prevalence of cancer surgery was higher in the former patients than in
the latter (42/72 vs. 24/67, p= 0.008). Surgeries involving bowel resection were more frequent in patient with post-surgical attack
(34/72 vs. 19/67, p = 0.024). Pre-surgical uric acid level and peri-surgical uric acid drop were significantly higher in patients with
post-surgical gout (8.5 ¡¾ 2.2. vs. 7.1 ¡¾ 2.1, p = 0.000; -2.4 ¡¾ 2.2 vs. -0.3 ¡¾ 1.3, p= 0.000). Also, pre-surgical colchicine and
allopurinol intakes were more frequently observed in patients without post-surgical gout (4/72 vs. 14/65, p= 0.010; 13/72 vs.
28/65, p = 0.002). Conclusion : Post-surgical gout attack was more frequent in patients who had cancer surgery, bowel resection,
and higher pre-surgical uric acid level, and larger peri-surgical uric acid drop. Regular allopurinol and colchicines intake before
surgery was more frequently observed in patients who did not develop post-surgical gout.
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