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Review
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Korean J Med. 2006;71(1):198-198.
- Autoantibody profile in systemic lupus erythematosus with vasculitis
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Seung-Ki Kwok, Sang-Won Son, Jeong Yo Min, Chang Dong Yeo, Soo-Hong Seo, Ji Hyeon Ju, Chong-Hyeon Yoon, Ho-Youn Kim, Sung-Hwan Park
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- Autoantibody profile in systemic lupus erythematosus with vasculitis
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중앙대학교 병원 내과학교실, 비뇨기과 교실, Cell genomics
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- Abstract
- This study was performed to determine the correlation between vasculitis and several autoantibodies which might participate in
pathogenesis of vasculitis in systemic lupus erythematosus (SLE). Forty-six patients with SLE accompanying vasculitis were
enrolled in this study (29 were patients with mesenteric vasculitis proven by abdominal CT and 12 with cutaneous vasculitis
proven by skin biopsy, 3 with CNS vasculitis suggested by brain MRI and 2 with vasculitis of lung proven by biopsy.)
Forty-seven SLE patients without vasculitis were enrolled as disease control. The disease activity was evaluated by the SLE
Disease Activity Index (SLEDAI). The prevalence of antibodies against cardiolipin, β2 glycoprotein 1, ds DNA, Sm, Ro, La, and
ribonucleoprotein(RNP) was assessed by enzyme-linked immunosorbent assay. Patients with definite antiphospholipid syndrome
were excluded in this study. According to cut off value, antibodies to cardiolipin(aCL) were present in 13 of 44 (29.5%) SLE
patients with vasculitis and in 3 of 41 (7.3 %) patients without vasculitis (p=0.01). Conversely, no significant correlations were
found between the presence of other autoantibodies and vasculitis. The results of this study suggest possible relations between
anti-phospholipid antibodies and development of vasculitis in SLE.
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