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Review
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Korean J Med. 2006;71(1):261-261.
- The Quality and Effect of Bowel Preparation in Whole versus Split-dose of Polyethylene Glycol Solution:A Randomized Prospective Single-blind Trial
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- The Quality and Effect of Bowel Preparation in Whole versus Split-dose of Polyethylene Glycol Solution:A Randomized Prospective Single-blind Trial
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Background /Aims: For early morning colonoscopy, ingestion of whole polyethylene glycol (PEG) solution on the day before procedure
has poor bowel preparation frequently. This study evaluated the safeness and efficacy of split-dose polyethylene glycol solution and
influence of colonoscopy procedure. Patients and Methods : A total 303 consecutive medical check-up patients were randomly assigned
to receive either 4L of polyethylene glycol solution (n=152; Group A) with a soft diet on the day before colonoscopy, or 3L of PEG solution
with a soft diet on the day before and then 1L of the PEG solution on the day of colonoscopy (n=151; Group B). Compliance, adverse
event, and tolerance of patients were assessed by questionnaire. The quality of the preparation, cecal intubation time and technical
difficulty during procedure was checked by three endoscopist, blinded to type of preparation, by using Ottawa bowel preparation quality
scale. Results : Complaint of nausea/vomiting and abdominal bloating were high in group A (p<0.05), but the other complaint, compliance,
the overall tolerance of patients were no difference in both groups (p>0.05). The quality of the preparation, cecal intubation time, and the
technical difficulty during procedure were significantly better in Group B (Table1). Also willingness of colonoscopy in the future was
significantly high in Group B (Table 1). Conclusions : Split-dose preparation by using PEG solution are suitable for early morning
colonoscopy. This is not affect compliance and adverse event(esp. sleep disturbance) of patients.
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