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Review
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Korean J Med. 2006;71(1):271-271.
- A Case of Hyperplastic Polyposis Coli Syndrome
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- A Case of Hyperplastic Polyposis Coli Syndrome
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Background : Hyperplastic polyposis coli syndrome (HPCS) is characterized by multiple, hyperplastic polyps in the colon. The
WHO definition of HPCS is at least five histologically diagnosed hyperplastic polyps proximal to the sigmoid colon, of which
two are greater than 10mm in diameter, or any number of hyperplastic polyps occurring proximal to the sigmoid colon in an
individual who has a first-degree relative with hyperplastic polyposis, or greater than 30 hyperplastic polyps of any size but
distributed throughout the colon. In 1977, Spjut and Estrada reported multiple hyperplastic polyps in the colonic mucosa of nine
patients for the first time. Its importance lies on the fact that patients with HPCS have a propensity to develop colorectal
caricinoma (CRC). Since then several authors have reported similar cases of multple colonic hyperplastic polyps, termed HPCS
in other countries. But, in Korea, there has been no case report about hyperplastic polyposis coli syndrome. So, herein we report
a case diagnosed as HPCS. Case : 74-year-old man was presented with intermittent lower abdominal pain, mucoid stool and
hematochezia ten times per day. In the past history, he received left nephrectomy due to renal tuberculosis and had chronic renal
failure and hypertension. He underwent colonoscopy which revealed more than one hundred, variable sized, sessile and
pedunculate, and round shaped polyps with erythematous surface in the sigmoid colon and rectum. Colonoscopic polypectomy
was performed for pathologic diagnosis and histologic finding revealed a characteristic histologic appearance of hyperplastic
polyps including micropapillary infoldings. Because patients with HPCS have a propensity to develop CRC and he complained
of recurrent mucoid stool and hematochezia, he received segmental resection from AV 5cm to AV 30cm. After that operation,
these symptoms were disappeared and he is being followed up in the out patient department.
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