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Review
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Korean J Med. 2006;71(1):277-277.
- 혈청 페리틴 농도의 상승과 동맥의 경직도 증가와의 상관관계
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Abstract Objective : Increased serum ferritin concentration can be associated with elevated oxidative stress and the
development of arteriosclerosis. We evaluated the relationship between increased ferritin level and arterial stiffness in a normal
population without known coronary and cerebrovascular diseases. Methods : We evaluated a total of 995 subjects (578 females;
mean age: 58?8 years). After excluding subjects with known cardiovascular and cerebrovascular disease, we analyzed data from
949 subjects. Risk factors of coronary arterial disease (CAD), serum cholesterol profiles, high-sensitive C-reactive protein,
fasting blood sugar (FBS) level, and ferritin concentrations were recorded. Arterial stiffness was assessed by brachial to ankle
pulse-wave velocity (baPWV). Results : A univariate analysis revealed the following: baPWV was correlated with conventional
clinical variables, including age (R=0.389, P<0.001), sex (R=0.099, P=0.002), blood pressure (systolic (R=0.614, P<0.001), diastolic
(R=0.417, P< 0.001)), triglyceride concentration (R=0.151, P< 0.001), and FBS level (R=0.184, P< 0.001). The baPWV was also
correlated with the 10-year cardiovascular risk score (R=0.419, P< 0.001) and serum ferritin concentration (R=0.184, P< 0.001).
The multivariate analysis demonstrated that baPWV was significantly correlated with serum ferritin concentration; this was
similar to other cardiovascular risk factors, including age, blood pressure, smoking, and FBS concentration. Conclusion :
Elevated serum ferritin concentration was associated with increased arterial stiffness in subjects without known coronary and
cerebrovascular diseases; this may contribute to increased cardiovascular risk. Keywards : Arteriosclerosis; Ferritin; Arterial
stiffness
Keywords :
