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Review
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Korean J Med. 2006;71(1):290-290.
- Plasma Nerve Growth Factor concentration is increased in Idiopathic Ventricular Arrhythmia
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- Plasma Nerve Growth Factor concentration is increased in Idiopathic Ventricular Arrhythmia
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
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- Abstract
- Background : It has been demonstrated that the plasma nerve growth factor (NGF) level increased after induction of ventricular
tachyarrhythmia (VT). However, the causal relationship between NGF and VT remains elusive. Thus, the aim of this study was
to investigate the relationship between plasma NGF level and inducibility of VT. Method : 24 patients (mean age: 44±14,
M:F=19:5) suspected to have VT underwent electrophysiologic study (EPS) were included. Blood samples were obtained before
EPS and plasma NGF concentrations were determined by ELISA. We compared plasma NGF levels between the subjects who
VT(VT group) was induce and the subjects who was not induced(Non VT group). Results : 1. The median plasma NGF level
was 17.5pg/ml ranging from 2.1 to 65.0 pg/ml . 2. The VT subjects included 12 patients with idiophathic ventricular tachycardia
and 2 with Brugada syndrome. 3. The plasma NGF level was significantly increased in VT group than Non VT group 〔median
(interquartile range), 18.7 (6.7-65.0) vs 10.3 (2.1-25.5) pg/ml, p<0.05〕. Conclusion : We suggest that the hypothesis that NGF
might be involved in the ventricular arrhythmogenesis.
Keywords :
