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Original Article
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Korean J Med. 2006;71(3):328-332.
- 증례:만성 호중구성 백혈병 1예
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홍순창, , , , , ,
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- A case of chronic neutrophilic leukemia
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Sun Chang Hong, Ji Hoon Kim, Jung Min Lee, Jun Oh Chung, Yun Kwon Kim, So Yon Kim, Gyeong In Lee
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고려대학교 의과대학 내과학교실
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- Abstract
- Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder characterized by
clonal proliferation of mature neutrophils, hepatosplenomegaly, elevated leukocyte alkaline
phosphatase score (ALP score) and a negative Philadelphia chromosome. To date, approximately
150 cases have been reported in the literature, including some cases presenting with a ‘leukemic’
state reflected by a neutrophilic reaction. The term ‘true’ CNL, recently introduced by Reilly,
highlights the need for more experience with CNL cases to improve the diagnostic criteria.
In Korea, about 10 cases have been reported in the literature and some of those cases did not
meet the WHO diagnostic criteria for CNL. We present a typical case of CNL in a 66-year-old
man who complained of general weakness and weight loss. On admission, the white blood cell
count from the peripheral blood was 175,600/L with 80% segmented neutrophils. The cytogenic
study was negative for the Philadelphia chromosome and had a normal karyotype.(Korean J
Med 71:328-332, 2006)
Key Words : Chronic neutophilic leukemia, Myeloproliferative disorder
Keywords :
