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Original Article
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Korean J Med. 2006;71(4):442-448.
- 증례:수년에 걸쳐 진행한 폐결절을 가진 불명열 환자에서의 항암화학요법 1예
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김유정, , , , , ,
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- Treatment with anti-cancer chemotherapy in a patient with fever of unknown origin and progressive pulmonary nodules
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Yu Jung Kim, Sunyoung Kim, Myoung Don Oh, Chul Gyu Yoo, Dae Seog Heo, Chul Woo Kim, Yung Jue Bang
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고려대학교 의과대학 내과학교실
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- Abstract
- Classic causes of fever of unknown origin (FUO) are infections, neoplasms, collagen vascular
diseases and drugs. However, large studies of FUO have consistently reported that a considerable
proportion of patients with FUO remain undiagnosed. We report a patient with a prolonged course
of FUO and progressive pulmonary nodules in whom extensive clinical and laboratory evaluation did
not reveal specific diagnosis. The patient had recurrent episodes of fever for more than three years,
and the pulmonary nodules gradually progressed in size and number despite administration of
antibiotics including antifungal and antituberculosis agents. Several pathologic examinations
demonstrated an organizing pneumonia or non-neoplastic lung parenchyma with lymphoplasmacytic
infiltration only. After a protracted course of disease, we thought that this patient might have
lymphoproliferative disorder, possibly EBV-associated, and started anti-cancer chemotherapy. He
was successfully treated with eight cycles of chemotherapy including cyclophosphamide, doxorubicin,
vincristine and prednisolone (CHOP).(Korean J Med 71:442-448, 2006)
Key Words : Fever of unknown origin, Chemotherapy, Lymphoproliferative disorder
Keywords :
