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Original Article
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Korean J Med. 2006;71(6):635-645.
- 원저:유지 혈액투석 환자에서 영양실조-염증 점수와 동맥경화의 연관성
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이현영, , , , , , , ,
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- Relationship of malnutrition-inflammation score with atherosclerosis in maintenance hemodialysis patients
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Hyun Young Lhee, Kyu Beck Lee, Hyang Kim, Chan Hee Jung, Eun Jung Rhee, Won Young Lee, Sun Woo Kim, Young Rea Lee, Kyung Choi
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고려대학교 의과대학 내과학교실
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- Abstract
- Background : Malnutrition-inflammation complex syndrome (MICS) is common in maintenance
hemodialysis (MHD) patients and may be related to a poor outcome. However, there is little evidence
showing MICS to be a risk factor for atherosclerosis. The aim of this study was to determine if
MICS is associated with the atherosclerotic markers such as abdominal aortic calcification (AAC) and
pulse wave velocity (PWV) in MHD patients.
Methods
: Eighty MHD patients were selected in Kangbuk Samsung Hospital (male:
female=50:30, age 58¡¾14 years). The nutritional status was assessed by the Subjective Global
Assessment (SGA), biochemical measurement and the normalized protein equivalent of the total
nitrogen appearance (nPNA). The presence of inflammatory reaction was assessed by the C-reactive
protein (CRP). The malnutrition-Inflammation Score (MIS) was used to assess MICS. A lateral
lumbar radiogram was used to evaluate the AAC index. Brachial-ankle (ba) PWV using automatic
device was performed.
Results
: Malnourished patients had a higher MIS than the well nourished patients (8.7¡¾3.6 vs.
4.0¡¾1.8, p<0.001). Patients with inflammation (CRP3 mg/L) showed a higher MIS than patients
without inflammation (7.6¡¾4.6 vs. 5.7¡¾3.3, p=0.045). There was no correlation between the MIS and
the AAC index (r=0.157, p=0.191) and baPWV (r= 0.144, p=0.323).
Conclusion
: These results suggest that the MIS is a useful marker of MICS in MHD patients.
However, the MIS was not directly related to the AAC index and baPWV. This report highlights the
importance of assessing the MICS and atherosclerosis in MHD patients.(Korean J Med 71:635-645,
2006)
Key Words : Hemodialysis, Malnutrition, Inflammation, Arteriosclerosis and Pulse wave velocity
Keywords :Hemodialysis, Malnutrition, Inflammation, Arteriosclerosis and Pulse wave velocity
