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Original Article
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Korean J Med. 2007;72(2):151-161.
- 원저: 수술 불가능한 췌장암 환자에서 생존율 및 예후 인자 분석
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박주경
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- Survival and prognostic factors of unresectable pancreatic cancer
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고려대학교 의과대학 내과학교실
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- Abstract
- Background: The prognosis of pancreatic cancer is very poor and it is generally unresectable when it is diagnosed. The aim of this study is to evaluate the prognostic significance of the clinical and laboratory variables, and the survival for unresectable pancreatic
cancer patients.
Methods
We retrospectively collected 245 unresectable pancreatic cancer patients who were diagnosed and had their disease pathologically proved between Jan. 1999 to Dec. 2004. They
underwent palliative interventions, including surgical bypass, palliative chemotherapy, palliative radiotherapy or supportive care. We also reviewed the medical records for the clinical and laboratory variables, and we investigated their survival data.
Results
The mean age of the patients was 60 years old (range: 28-87) and the median overall survival was 5.5 months. Age, performance status, tumor location, initial CA 19-9 level,
AJCC staging and the treatment modality had prognostic significance on univariate analysis. On multivariate analysis, performance status, tumor location, AJCC staging and the treatment
modality were independent prognostic factors. On the subgroup analysis, stage III patients who underwent concurrent chemoradiotherapy(CCRT, median OS 10.6 months) or chemotherapy
alone (12.7) showed survival benefit over the best supportive care (6.1). Stage IV patients who underwent chemotherapy (6.3) alone showed survival benefit over the best supportive care (3.4).
Conclusions
The performance status, AJCC staging, tumor location and the treatment modality were independent prognostic factors of unresectable pancreatic cancer. The patients who received chemotherapy or CCRT showed better survival than those who received the best supportive care group. Therefore, active treatment modality should be considered for unresectable pancreatic cancer.(Korean J Med 72:151-161, 2007)
Key Words : Pancreatic cancer, CA 19-9, Staging, Chemotherapy, Radiotherapy
Keywords :Pancreatic cancer, CA 19-9, Staging, Chemotherapy, Radiotherapy
