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Original Article
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Korean J Med. 2007;72(3):272-280.
- 원저 : 췌관내 유두상 점액 종양의 임상상 및 병리학적 특징: 악성 종양 예측인자를 중심으로
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윤원재, , , , , , , , ,
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- Clinicopathological features of intraductal papillary mucinous neoplasms of the pancreas:an emphasis on predictors of malignancy
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Won Jae Yoon, Jun Kyu Lee, Joo Kyung Park, Sang Hyub Lee, Ji Kon Ryu, Yong Tae Kim, Yong Bum Yoon, Jin Young Jang, Sun Whe Kim, Woo Ho Kim
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고려대학교 의과대학 내과학교실
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- Abstract
- Background : Intraductal papillary mucinous neoplasm of the pancrea (IPMN) is a newly recognized category of pancreatic exocrine tumors with a favorable prognosis. We conducted this study to evaluate clinicopathological features of IPMNs and to evaluate clinical factors associated with malignant IPMNs.
Methods
: We retrospectively evaluated 91 patients (55 males, mean age 61.6 years) who were diagnosed with IPMNs with histological confirmation from 1993 to 2004.
Results
: Fifty-eight cases were incidentally found, whereas 33 cases were symptomatic. Pathology revealed adenoma in 19 cases, IPMN with moderate dysplasia in 50 cases, noninvasive carcinoma in 8 cases, and invasive carcinoma in 14 cases. In main duct type (n=13) and combined type IPMNs (n=5), visible mucin secretion as seen on endoscopy indicated a borderline association with malignancy; a large tumor diameter (≥30 mm) was associated with malignancy. In branch duct type IPMNs (n=73), the presence of symptoms or signs, the presence of mural nodules, a large tumor diameter (≥27 mm) and a larger main pancreatic duct diameter (≥4 mm) were associated with malignancy.
Conclusions
: In IPMNs involving the main pancreatic duct, a large tumor diameter (≥30 mm) is associated with malignancy. In branch duct type IPMNs, the presence of symptoms or signs, the presence of mural nodules, a large tumor diameter (≥27 mm) and a large main pancreatic duct diameter (≥4 mm) are associated with malignancy.(Korean J Med 72:272-280, 2007)
Key Words : Pancreas, Neoplasms
Keywords :Pancreas, Neoplasms
