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Original Article
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Korean J Med. 2007;72(2):322-326.
- 증례 : 악성림프종 치료 과정에서 병발된 급성골수성백혈병 1예
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박윤정
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- Development of acute myeloid leukemia during the treatment of non-Hodgkin’s lymphoma
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고려대학교 의과대학 내과학교실
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- Abstract
- The widespread use of intensive combination chemotherapy with/without radiation therapy has enhanced the long-term survival of the cancer patient. However, cytotoxic therapy has led to the emergence of late-complications, such as therapy-related acute myeloid leukemia (t-AML). We experienced a case of t-AML with inv(16) and the subsequent development of the t(9;22) abnormality. This is the first report of the coexistence of these abnormalities in t-AML. A forty-eight year old woman was diagnosed as having t-AML during treatment of low-grade non-Hodgkin's lymphoma.
The patient showed pancytopenia 10 months after the initiation of chemotherapy with a topoisomerase II inhibitor. After the patient achieved complete remission, she received allogeneic hematopoietic stem cell transplantation from a sibling, and has since been in excellent clinical condition. During a follow-up of patients treated for primary malignancies, the possibility of t-AML arising should always be considered. Not only a morphologic evaluation but also a cytogenetic study is necessary to study pancytopenia that may follow chemotherapy.(Korean J Med 72:S322-S326, 2007)
Key Words : t-AML, Non-Hodgkin's lymphoma, Stem cell transplantation, Inv(16) and (9;22)
Keywords :t-AML, Non-Hodgkin's lymphoma, Stem cell transplantation, Inv(16) and (9, 22)
