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Original Article
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Korean J Med. 2008;74(2):146-153.
- 원저 : 결장 샘암종에서 Claudin-1, β-catenin과 E-cadherin의 발현
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차은정 . 장규윤 . 최하나 . 김경열 . 최금하 . 황성호 . 문우성 . 강명재 . 이동, , , , , , , , ,
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- Expression of claudin-1, β-catenin and E-cadherin in adenocarcinoma of the colon
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Eun Jung Cha, Kyu Yun Jang, Ha Na Choi, M.S., Kyung Ryul Kim, Keum Ha Choi, Sung Ho Hwang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee
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서울대학교 의과대학 내과학교실1, 경희대학교 의과대학 내과학교실2
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- Abstract
- Background/Aims : Disruption of the cell-to-cell junction with changes in the expression of the junctional proteins is the hallmark of cancer invasion and metastasis. To investigate the roles of claudin-1, β-catenin and E-cadherin in adenocarcinoma of the colon, the relationship of their expression with clinical and pathological factors were examined.
Methods : The expression of claudin-1, β-catenin and E-cadherin were examined in 47 cases of adenocarcinoma of the colon by immunohistochemical staining.
Results : A reduced claudin-1 expression was associated with advanced lymph node metastasis (p=0.019) and histological dedifferentiation at the invasive front (p=0.030). A reduced expression of β-catenin and E-cadherin were correlated with histological dedifferentiation (p=0.012, p=0.010, respectively). The reduced expression of two or more proteins was correlated with the histological findings of dedifferentiation (p=0.030).
Conclusions : These results suggest that loss of claudin-1, β-catenin and E-cadherin expression may be correlated with the progression of adenocarcinoma of the colon and associated with an advanced histological grade.
Keywords :Colon, Adenocarcinoma, Claudin 1, beta Catenin, E-cadherins
