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Original Article
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Korean J Med. 2008;74(1):179-183.
- 증례 : 제한효소 절편길이 다형성 검사로 확인된 위양성 다제내성결핵 1예
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홍석찬, 김미나, 박영길, 조경욱, 정용필, 김원동, 심태선
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- A case of false-positive multidrug-resistant tuberculosis confirmed by restriction ragment length polymorphism analysis
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Seok Chan Hong, Mi-Na Kim, Young Kil Park, Kyung Uk Jo, Yong Pil Jeong, Won Dong Kim, Tae Sun Shim
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경희대학교 의과대학 순환기내과학교실
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- Abstract
- Microbiological confirmation is the gold standard method for the diagnosis of tuberculosis (TB), but there are numerous reports of false-positive cultures for Mycobacterium tuberculosis. Although the prevalence of TB in Korea is still high, the occurrence of false-positive cultures for M. tuberculosis has rarely been recognized or reported. We report a false-positive culture of multidrug-resistant M. tuberculosis due to cross-contamination, as confirmed by restriction fragment length polymorphism (RFLP) analysis. Clinicians should always suspect the possibility of a false-positive culture result for M. tuberculosis when there is a discrepancy between the clinical and bacteriological results, with low colony counts on sputum culture for M. tuberculosis.
Keywords :Mycobacterium tuberculosis, False-positive culture, Crossover contamination, RFLP analysis
