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Original Article
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Korean J Med. 2008;75(4):479-483.
- 증례: 갈색세포종의 임상 표현을 보인 부신 피질 선종 1예
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정문경 . 김용철 . 전은경 . 이근호 . 맹이소 . 한제호 . 문성대, , , , , ,
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- A case of adrenocortical adenoma clinically mimicking pheochromocytoma
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Mun Kyung Chung, Yong Cheol Kim, Eun Kyoung Jeon, Keun Ho Lee, Lee So Maeng, Je Ho Han, Sung Dae Moon
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경희대학교 의과대학 순환기내과학교실
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- Abstract
- The coexpression of cortical and medullary features in a single adrenal cortical cell has been recognized, leading to
terms such as cortico-medullary cells. Here, we reported a case of adrenocortical adenoma consisting of cortico-medullary
cells that clinically mimicked pheochromocytoma. A 52-year-old woman was admitted to our hospital complaining of an
8-month history of paroxysmal palpitation with refractory hypertension. A 24-hour urine study revealed increased
norepinephrine and metanephrine levels. Computed tomography of the abdomen revealed a 1.0¡¿0.9-cm mass in the left
adrenal gland. The patient subsequently underwent unilateral laparoscopic adrenalectomy for a presumptive pheochromocytoma.
Light microscopic findings of the left adrenal mass indicated an adrenocortical adenoma, but electron microscopy
identified lipid vacuoles and smooth endoplasmic reticulum, along with dense core neurosecretory granules, so-called
cortico-medullary cells. This is the first report of the detection of cortico-medullary cells in adrenocortical adenoma
presenting as pheochromocytoma in Korea. (Korean J Med 75:479-483, 2008)
Keywords :Hypertension, Pheochromocytoma, Adrenocortical adenoma
