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Original Article
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Korean J Med. 2008;75(5):515-524.
- 종설: 류마티스관절염의 유전적 요인
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이 혜 순
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- Genetic susceptibility factors of rheumatoid arthritis
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Hye-Soon Lee
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1Department of Cardiology, Catholic University of Daegu College of Medicine, Daegu, Korea
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- Abstract
- Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly involves the joints. Although the full etiology remains unclear, both genetic and environmental factors contribute to disease. Recently, genetic studies of RA, which include whole-genome linkage study, candidate gene association study, and especially genome-wide association study, made much progress through the advances in technology and large collection of case-controls. These various approaches provided new susceptible genes such as PTPN22, PADI4, STAT4, TNFAIP3, TRAF1-C5, CD40 gene in addition to HLA-DRB1. This review will cover an update in recent progress in RA genetics, focusing mainly on the several novel loci. (Korean J Med 75:515-524, 2008)
Keywords :Rheumatoid arthritis, Gene, Genome-wide association study
