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Original Article
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Korean J Med. 2008;75(5):539-545.
- 원저: 표면 항원 음성인 건강 검진 수진자와 만성 음주자에서 B형 간염 바이러스 잠재 감염
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오성남.연종은.한우식.최도원.김지현.김연호.박종재.김재선.변관수.박영태, , , , , , , , ,
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- Prevalence of occult HBV infection in alcholic and non-alcoholic subjects lacking the hepatitis B surface antigen
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Sung Nam Oh, Jong Eun Yeon, Woo Sik Han, Do Won Choi, Ji Hyun Kim, Yeoun Ho Kim, Jong-Jae Park, Jae Seon Kim, Kwan Soo Byun, Young-Tae Bak
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서울적십자병원 내과
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- Abstract
- Backgrounds/Aims: Hepatitis B virus (HBV) infection and chronic alcoholism are major risk factors for chronic liver disease in Korea.
Methods: We investigated the prevalence of occult HBV infection in 198 non-alcoholic (group I) and 85 chronic alcoholic subjects (group II), none of whom showed the hepatitis B surface antigen (HBsAg). Among chronic alcoholics, 25 patients showed cirrhosis. Using serum samples stored at -70℃, liver enzymes, anti-Hbs, and IgG anti-HBc were measured via EIA and serum HBV DNA was quantified via real time PCR.
Results: IgG anti-HBc seropositivity, an indicator of past infection, was higher in group II (64.7%) than in group I (43.4%; p<0.01). Eleven of 283 patients (3.2%) were seropositive for HBV DNA, indicating occult infection, but this value did not differ between groups (group I: 3.5%, 7/198; group II: 4.7%, 4/85; p=0.64). In group II, HBV DNA seropositivity was higher in cirrhotic patients (12%, 3/25) than in non-cirrhotic alcoholic liver disease (1.7%, 1/60; p=0.074).
Conclusions: Past HBV infection was more prevalent in alcoholics than non-alcoholics, but the prevalence of occult HBV infection did not differ between groups. However, alcoholics with cirrhosis tended to show a higher prevalence of occult HBV infection. (Korean J Med 75:539-545, 2008)
Keywords :Alcoholism, Hepatitis B virus, Occult infection
