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Original Article
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Korean J Med. 2008;75(5):553-558.
- 원저: 건강한 공여자에서 말초조혈모세포 채집시 G-CSF의 투여기간의 효과
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이성은.박진영.이승원.최익준.이석주.박종원, , , , ,
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- Effect of the G-CSF schedule for harvesting peripheral blood progenitor cells from healthy donors
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Sung Eun Lee, Jin Young Park, Sung Won Lee, Ik Jun Choi, Seok Ju Lee, Chong Won Park
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울산의대 울산대학교병원 내과, 영상의학과1
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- Abstract
- Background/Aims: Peripheral blood progenitor cells (PBSC) have been used instead of bone marrow cells for allogeneic transplantation. Progenitor cells are mobilized using granulocyte colony stimulating factor (G-CSF). Kinetic studies of G-CSF have shown that the CD34+ cells peak on day 5, although the optimal time for harvesting has not been established.
Methods: We compared two mobilization schedules using G-CSF. In groups I and II, G-CSF 10 µg/kg/day was administered subcutaneously for 3 or 4 days, respectively, and leukapheresis was performed the next day.
Results: In groups I and II, a respective mean number of 5.84 × 106 and 10.76 × 106 circulating CD34+ cells per kilogram of the recipient’s weight was collected by leukapheresis. The yield of the two collections did not differ significantly (p=0.386).
Conclusion: This study suggested that the two mobilization schedules are equally effective. To avoid prolonged exposure to G-CSF, the day 4 collection schedule is the preferred mobilization strategy. (Korean J Med 75:553-558, 2008)
Keywords :Peripheral blood stem cells, Mobilization, Granulocyte colony-stimulating factor, Healthy donor
