-
Original Article
-
Korean J Med. 2008;75(5):592-596.
- 증례: Rifampicin에 의해 유발된 간질성 폐렴 1예
-
정정임.정복현.김미혜.박용진.허태윤.류대식.강길현, , , , , ,
-
- A case of rifampicin-induced interstitial pneumonitis
-
Jeong Ihm Jeong, Bock Hyun Jung, Mi Hye Kim, Yong Jin Park, Tae Yun Hea, Dae Sik Rhui, Gil Hyun Kang
-
경희대학교 의과대학 순환기내과학교실
-
- Abstract
- Rifampicin is a powerful agent for the treatment of pulmonary tuberculosis. However, it may induce several adverse effects, including rare cases of lung toxicity. Here, we report a case of rifampicin-induced interstitial pneumonitis. A 57-year-old woman diagnosed with cerebellar tuberculoma developed progressive dyspnea after the 5th day of anti-tuberculosis medication. Chest X-ray revealed newly developed ground glass opacities on both lower lung fields. Drug-induced pneumonitis was suspected and all anti-tuberculosis medications were halted. Transbronchial lung biopsy was consistent with desquamative interstitial pneumonitis. After clinical improvement, a rechallenge test with each anti-tuberculosis medication was attempted. No primary anti-tuberculosis drug except rifampicin triggered recurrence of symptoms, supporting a diagnosis of rifampicin-induced interstitial pneumonitis. Clinicians should be aware of this rare, but serious, side effect of rifampicin treatment. (Korean J Med 75:592-596, 2008)
Keywords :Drug-induced pneumonitis, Rifampicin, Tuberculosis
