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Original Article
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Korean J Med. 2009;76(6):643-648.
- 궤양성 대장염의 병태생리 - 유전 및 면역 관련성
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서검석, 최석채
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- Pathophysiology of ulcerative colitis - Relationship with genetics and immunity
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Geom Seog Seo, Suck Chei Choi
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- Abstract
- dysregulated immune responses against intraluminal bacterial antigens. Recently, numerous new genes have been identified as involved in the genetic susceptibility to ulcerative colitis, including IL-23R, MST1, IL-12B (p40), NKX2-3, and STAT3. Experimental studies of ulcerative colitis point to an excessive T-cell response to antigenic stimulus resulting in damage to host intestinal tissue. The T-cell response in ulcerative colitis appears to be TH2 dominant (IL-5, IL-13) and mediated by specialized cells, such as NK T-cells. The characterization of these novel genes and immunologic basis should lead to the identification of therapeutic agents and a better clinical assessment of phenotype and prognosis in patients with ulcerative colitis.
Keywords :Ulcerative colitis, Genes, Immune response, T-cell, Genetic susceptibility
