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Original Article
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Korean J Med. 2009;76(6):682-684.
- 아스피린 저항성: 단순한 검사 소견인가 또는 중요한 임상 기준인가?
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정영훈
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- Implication of aspirin resistance: Simple laboratory finding or important clinical criteria?
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Young-Hoon Jeong
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- Abstract
- Aspirin resistance defined by light transmittance aggregometry (LTA) or urinary 11-dehydro-thromboxane B2 has been associated with an increased risk of adverse clinical events. However, aspirin resistance based on the point-of-care VerifyNow-Aspirin assay (aspirin reaction unit ≥550) shows poor sensitivity compared with LTA. In aspirin-treated patients, activation by cyclooxygenase–independent pathways may be associated with residual platelet reactivity, which may cause adverse clinical outcomes in some portion. A large-scale, prospective study using several platelet function assays should be performed to establish the long-term clinical significance of antiplatelet resistance in Korean patients treated with coronary stenting. Accordingly, we can apply tailored antiplatelet therapy in resistant patients.
Keywords :Aspirin resistance, VerifyNow-Aspirin, Tailored antiplatelet therapy
