The Korean Journal of Internal Medicine

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Original Article
Korean J Med. 2009;76(1):190-194.
골수 및 림프절생검에서 섬유소 고리 육아종 소견을 보인 급성 Q열 1예
조오현, 최영실, 김 탁, 박기호, 오 련, 지현숙, 김양수
A case of acute Q fever with fibrin-ring granuloma in the bone marrow and lymph node biopsy
Oh Hyun Cho, Young Sill Choi, Tark Kim, Ki Ho Park, Ryan Oh, Hyun Sook Chi, Yang Soo Kim


Abstract
Q fever is a zoonotic infection caused by Coxiella burnetii. Acute Q fever usually develops as a self-limited flu-like illness, atypical pneumonia, or hepatitis. We experienced a case of Q fever in a 50-year-old male who had a prolonged fever. The bone marrow and lymph node biopsy revealed fibrin-ring granulomas, which is a distinct finding of Q fever. The diagnosis was proven by high titers of C. burnetii anti-phase II antibody (IgM 1:512 and IgG >1:2,048) and positive nested PCR for the com-1 gene. Q fever is rare in Korea, but should be considered in the differential diagnosis of fever of unknown origin. (Korean J Med 76:S190-S194, 2009)

Keywords :Q fever, Coxiella burnetii, Fibrin-ring granuloma
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